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Bladder sphincter dyssynergia (also known as detrusor sphincter dyssynergia (DSD) (the ICS standard terminology agreed 1998) [1] and neurogenic detrusor overactivity (NDO)) is a consequence of a neurological pathology such as spinal injury [2] or multiple sclerosis [3] which disrupts central nervous system regulation of the micturition (urination) reflex resulting in dyscoordination of the ...
For example, a patient complaining of urinary urgency (or rushing to the toilet), with increased frequency of urination can have overactive bladder syndrome. The cause of this might be detrusor overactivity, in which the bladder muscle (the detrusor) contracts unexpectedly during bladder filling. Urodynamics can be used to confirm the presence ...
Neurogenic bladder is common with spinal cord injury and multiple sclerosis. [11] Rates of some type of urinary dysfunction surpass 80% one year after spinal cord injury. [ 7 ] Among patients with multiple sclerosis, 20–25% will develop neurogenic bladder although the type and severity bladder dysfunction is variable.
The efficacy of solifenacin to treat neurogenic detrusor overactivity (NDO) was established in two clinical trials with a total of 95 pediatric NDO participants, ages two to 17 years old. [2] The studies were designed to measure (as a primary efficacy endpoint) the maximum amount of urine the bladder could hold after 24 weeks of treatment. [2]
Overactive bladder (OAB) is a common condition where there is a frequent feeling of needing to urinate to a degree that it negatively affects a person's life. [2] The frequent need to urinate may occur during the day, at night , or both. [ 4 ]
The detrusor is a muscular sac that stores urine and squeezes to empty. Connected to the bottom or next of the bladder, the sphincter is a circular group of muscles that automatically stays contracted to hold the urine in. It will automatically relax when the detrusor contracts to let the urine into the urethra.
The bladder also contains β 3 adrenergic receptors, and pharmacological agonists of this receptor are used to treat overactive bladder. The mucosa of the urinary bladder may herniate through the detrusor muscle. [6] This is most often an acquired condition due to high pressure in the urinary bladder, damage, or existing connective tissue ...
Neurogenic bladder dysfunction can involve a malfunctioning urethral sphincter. [8] Urge incontinence can happen when the urethra cannot hold the urine in as the bladder contracts uncontrollably. [9] Retrograde ejaculation can occur in men when the internal urethral sphincter fails to adequately contract during ejaculation. [3]