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An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. [1] [2] It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS.
Schematic of the Emulate liver-chip [4] Emulate's Organs-on-Chips technology has been used to recreate the function of a variety of different organs, including the liver, intestine, brain, kidney, and lung. [5] The company's Organ-Chips are about the size of a AA battery and feature two fluidic channels that create the flow of blood and other ...
Schematic drawing of a lung-on-a-chip. The membrane in the middle can be stretched by vacuum in the two side chambers. Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1]
A prominent example of an intestine-on-a-chip system relying on architectural cues is the homeostatic mini-intestines by Nikolaev et al. [24] They use microfabricated intestine-on-a-chip devices with a hydrogel chamber. The collagen-Matrigel-mix hydrogel is laser-ablated to generate a microchannel for a tubular intestinal lumen with crypt ...
Human diseases could soon be modeled in an electronic "organ-on-a-chip", with a new generation of research to replace animal testing. [634] [635] Astronomers report that HD 40307 g, a super-Earth exoplanet 42 light-years away from Earth, is within the habitable zone of its host star HD 40307 and may be "just right to support life". [636] [637]
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This article was the subject of a Wiki Education Foundation-supported course assignment, between 29 March 2021 and 4 June 2021. Further details are available on the course page. Student editor(s): Khunkhunk. Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT 13:17, 18 January 2022 (UTC)
Pages in category "System on a chip" The following 38 pages are in this category, out of 38 total. This list may not reflect recent changes. ...