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This gene encodes a protein that is a transmembrane receptor for growth hormone. [10] [11] Binding of growth hormone to the receptor leads to reorientation of a pre-assembled receptor dimer dimerization (the receptor may however also exist as monomers on the cell surface [12]) and the activation of an intra- and intercellular signal transduction pathway leading to growth. [13]
It appears that, in structure, GH is evolutionarily homologous to prolactin and chorionic somatomammotropin. Despite marked structural similarities between growth hormone from different species, only human and Old World monkey growth hormones have significant effects on the human growth hormone receptor. [9]
14602 Ensembl ENSG00000106128 ENSMUSG00000004654 UniProt Q02643 P32082 RefSeq (mRNA) NM_000823 NM_001009824 NM_001003685 RefSeq (protein) NP_000814 NP_001003685 Location (UCSC) Chr 7: 30.94 – 30.99 Mb Chr 6: 55.35 – 55.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone ...
Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". [ 5 ] [ 6 ] The role of GHS-R is thought to be in regulating energy homeostasis and body weight. [ 7 ]
Growth hormone-binding protein (GHBP) is a soluble carrier protein for growth hormone (GH). [1] The full range of functions of GHBP remains to be determined. [2] [3] However, current research suggests that the protein is associated with regulation of the GH availability and half-life in the circulatory system, as well as modulating GH receptor function.
Ghrelin was discovered after the ghrelin receptor (called growth hormone secretagogue type 1A receptor or GHS-R) was determined in 1999. [6] The hormone name is based on its role as a growth hormone-releasing peptide, with reference to the Proto-Indo-European root gʰre-, meaning "to grow".
For more information, patients treated with cadaver-derived human growth hormone in the U.S. can call the National Institute of Diabetes and Digestive and Kidney Diseases at 1-800-860-8747 or ...
5-DHT or DHT is a male reproductive hormone that targets the prostate gland, bulbourethral gland, seminal vesicles, penis and scrotum and promotes growth/mitosis/cell maturation and differentiation. Testosterone is converted to 5-DHT by 5alpha-reductase, usually with in the target tissues of 5-DHT because of the need for high concentrations of ...
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