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The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus . Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac -LYASSNPApY- NH2 peptide in the juxtamembrane region of the insulin receptor.
Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. [ 1 ]
The phosphorylation of specific tyrosine residues within the activated receptor creates binding sites for Src homology 2 (SH2) domain- and phosphotyrosine binding (PTB) domain-containing proteins. [ 10 ] [ 11 ] Specific proteins containing these domains include Src and phospholipase C γ.
The essential spliceosome component U2AF bound to a short polypyrimidine RNA fragment. The polypyrimidine tract is a region of pre-messenger RNA (mRNA) that promotes the assembly of the spliceosome, the protein complex specialized for carrying out RNA splicing during the process of post-transcriptional modification.
PTBP1 has been shown to interact with HNRPK, [9] PCBP2, [9] SFPQ [10] [11] and HNRNPL. [9] [12]This gene is targeted by the microRNA miR-124.During neuronal differentiation, miR-124 reduces PTBP1 levels, leading to the accumulation of correctly spliced PTBP2 mRNA and a dramatic increase in PTBP2 protein.
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. [2]
A federal judge paused the child sexual abuse case involving President-elect Donald Trump's education secretary pick Linda McMahon, her husband Vince McMahon and World Wrestling Entertainment (WWE).
Under the minimalist program, syntactic structures are formed by iterative applications of the syntactic operation Merge, which serves to connect two elements into one. [7] To yield a linguistic expression , lexemes are selected out of the lexicon and make a (non-ordered) set of syntactic objects called a lexical array , and a structure is ...