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Pyrrole is a heterocyclic, aromatic, organic compound, a five-membered ring with the formula C 4 H 4 NH. [3] It is a colorless volatile liquid that darkens readily upon exposure to air. Substituted derivatives are also called pyrroles, e.g., N -methylpyrrole, C 4 H 4 NCH 3 .
The Knorr pyrrole synthesis is a widely used chemical reaction that synthesizes substituted pyrroles (3). [ 1 ] [ 2 ] [ 3 ] The method involves the reaction of an α- amino - ketone (1) and a compound containing an electron-withdrawing group (e.g. an ester as shown) α to a carbonyl group (2) .
In organic chemistry, the Bohlmann–Rahtz pyridine synthesis is a reaction that generates substituted pyridines in two steps, first a condensation reaction between an enamine and an ethynylketone to form an aminodiene intermediate, which after heat-induced E/Z isomerization undergoes a cyclodehydration to yield 2,3,6-trisubstituted pyridines.
This difference is partly related to the lower symmetry of the individual pyridine molecule (C 2v vs D 6h for benzene). A trihydrate (pyridine·3H 2 O) is known; it also crystallizes in an orthorhombic system in the space group Pbca, lattice parameters a = 1244 pm, b = 1783 pm, c = 679 pm and eight formula units per unit cell (measured at 223 K).
In organic chemistry, the Paal–Knorr synthesis is a reaction used to synthesize substituted furans, pyrroles, or thiophenes from 1,4-diketones.It is a synthetically valuable method for obtaining substituted furans and pyrroles, which are common structural components of many natural products.
A library of substituted pyrrole analogs can be quickly produced by using continuous flow chemistry (reaction times of around 8 min.). [10] The advantage of using this method, as opposed to the in-flask synthesis, is that this one does not require the work-up and purification of several intermediates, and could therefore lead to a higher ...
Polypyrrole Pyrrole can be polymerised electrochemically. [1] Polypyrrole (PPy) is an organic polymer obtained by oxidative polymerization of pyrrole. It is a solid with the formula H(C 4 H 2 NH) n H. It is an intrinsically conducting polymer, used in electronics, optical, biological and medical fields. [2] [3]
The Hantzsch pyridine synthesis or Hantzsch dihydropyridine synthesis is a multi-component organic reaction between an aldehyde such as formaldehyde, 2 equivalents of a β-keto ester such as ethyl acetoacetate and a nitrogen donor such as ammonium acetate or ammonia.