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Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. [2] This results in a low platelet count , low red blood cells due to their breakdown , and often kidney , heart , and brain dysfunction. [ 1 ]
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia accompanied by variable neurological dysfunction, kidney failure, and fever. It is caused by severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS13.
Another form is thrombotic thrombocytopenic purpura. [citation needed] Diagnosis
Treatment of thrombotic thrombocytopenic purpura (TTP) is a medical emergency, since the associated hemolytic anemia and platelet activation can lead to kidney failure and changes in the level of consciousness. Treatment of TTP was revolutionized in the 1980s with the application of plasmapheresis.
Upshaw–Schulman syndrome (USS) is the recessively inherited form of thrombotic thrombocytopenic purpura (TTP), a rare and complex blood coagulation disease. USS is caused by the absence of the ADAMTS13 protease resulting in the persistence of ultra large von Willebrand factor multimers (ULvWF), causing episodes of acute thrombotic microangiopathy with disseminated multiple small vessel ...
As in non-pregnant individuals, ITP in pregnancy is a diagnosis of exclusion and other potential causes of low platelets in pregnancy require consideration. These include obstetrical causes such as pre-eclampsia, HELLP syndrome (hemolysis, elevated liver enzymes and low platelets), or thrombotic microangiopathies that may occur during pregnancy ...
Eli Moschcowitz (2 August 1879 – 23 February 1964) [1] was an American doctor best known for his role in discovering thrombotic thrombocytopenic purpura (TTP), which was originally called "Moschcowitz syndrome". [2] He is also known for having an early role in the development of psychosomatic medicine. [3] [4] [5]
Thrombotic thrombocytopenic purpura, a blood disorder Tristetraprolin , a protein Thymidine triphosphate , one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA