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Despite all of the below potential treatment options, recent literature highlights that (for most patients) metastatic pheochromocytoma is slow-growing. In patients with minimal disease burden, a "watch and wait" approach with frequent imaging to monitor disease is favorable, withholding treatment until evidence of progression is visualized. [138]
Serotonin syndrome, in which an excess of serotonin in the synapses causes a similar crisis of hypertension and mental confusion, could be confused with an adrenergic storm. Serotonin, being a tryptamine (non-catecholamine) involved in higher brain functions, can cause dangerous hypertension and tachycardia from its effects on the sympathetic ...
Excess catecholamines, when released directly by nerves that stimulate cardiac muscle cells, have a toxic effect and can lead to decreased cardiac muscular function or "stunning". [ 11 ] [ 12 ] Further, this adrenaline surge triggers the arteries to tighten , thereby raising blood pressure and placing more stress on the heart, and may lead to ...
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The adrenal cortex is composed of three distinct layers of endocrine cells which produce critical steroid hormones.These include the glucocorticoids, which are critical for regulation of blood sugar and the immune system, as well as response to physiological stress; the mineralcorticoid aldosterone, which regulates blood pressure and kidney function; and certain sex hormones.
Catecholamines are produced mainly by the chromaffin cells of the adrenal medulla and the postganglionic fibers of the sympathetic nervous system. Dopamine, which acts as a neurotransmitter in the central nervous system, is largely produced in neuronal cell bodies in two areas of the brainstem: the ventral tegmental area and the substantia nigra, the latter of which contains neuromelanin ...
Scientific advances helped avert 4.1 million deaths from cancer in the 30 years between 1991 and 2021 according to a new report, but the disease continues to be a public health challenge. The ...
Metirosine has been shown to suppress catecholamine synthesis and alleviate symptoms related to catecholamine excess, including hypertension, headache, tachycardia, constipation, and tremor. [12] Metirosine is primarily used to reduce these symptoms in patients with pheochromocytoma. [13]