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The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel diseaseBiological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [1]
Lubiprostone, sold under the brand name Amitiza among others, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. The drug is owned by Mallinckrodt and is marketed by Takeda Pharmaceutical Company.
Olorinab (APD371) is a drug being developed by Arena Pharmaceuticals for the treatment of gastrointestinal pain associated with Crohn's disease and irritable bowel syndrome. [1] It acts as a potent and selective cannabinoid CB 2 receptor agonist and is claimed to be orally active and peripherally selective.
Otilonium bromide is a drug used to treat abdominal pain caused by irritable bowel syndrome. It is an antispasmodic , which is useful to treat the symptoms of irritable bowel syndrome by reducing abdominal spasms ( colic ), bloating, pain, and gut motility.
Pfizer has also sought regulatory approvals for the drug in Australia, India and the UK, among others. Leerink Partners in October estimated the drug's 2030 sales at $2.2 billion.
Its use in IBS is thought to be due to its calming ability for patients that have IBS symptoms that are worsened by anxiety. Clidinium bromide is a synthetic quaternary ammonium antimuscarinic, [5] a sub-class of a family of drugs known as anticholinergics. It treats IBS by decreasing gastrointestinal motility. Chlordiazepoxide can be habit ...