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CYB004, or CYB-004, also known as deuterated dimethyltryptamine (dDMT), is a serotonergic psychedelic related to dimethyltryptamine (DMT) which is under development for the treatment of generalized anxiety disorder. [1] [4] [2] [3] It is administered by inhalation or intravenous injection. [1] [2]
These two studies are some of the first large controlled studies measuring the effects of psychedelic therapy on depression and anxiety in cancer patients. [64] Across clinician-ratings and self-ratings, the psychedelic treatment produced statistically significant lowered anxiety and depression, with sustenance for at least 6 months.
[162] [164] [165] Similarly to DMT, 5-MeO-DMT is a biased agonist of the serotonin 5-HT 2A receptor, with minimal β-arrestin2 recruitment, and likewise has been associated with little tolerance to its hallucinogenic effects. [166] [140] As DMT has been shown to have slightly better efficacy (EC 50) at human serotonin 2C receptor than at the 2A ...
5-MeO-DMT is being developed and evaluated for potential therapeutic effects in patients with treatment-resistant depression (TRD). [56] Biopharmaceutical company GH Research has sponsored a completed phase 1 study in healthy volunteers [ 57 ] and phase 1/2 study in TRD patients where 87.5% of patients with TRD were brought into remission on ...
Such effects can be useful in managing the effects of serotonergic psychedelics, including clinically in the case of benzodiazepines. [3] [31] While employed by recreational users for harm-reduction purposes, the use of trip killers to abort the effects of psychedelics and other hallucinogens is not fully characterized and could pose medical risks.
To date studies have explored the utility of psilocybin in a variety of diseases, including TRD, [14] [15] smoking addiction, [16] [17] and anxiety and depression in people with cancer diagnoses. [18] LSD is being tested in phase 2 trials for cluster headaches and anxiety. [19] DMT is being studied for depression. [20]
6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. [ 1 ] [ 2 ] It is the 6- methoxy derivative of the serotonergic psychedelic N , N -dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT .
Midomafetamine (MDMA; "ecstasy") – serotonin, norepinephrine, and dopamine releasing agent, weak serotonin 5-HT 2A, 5-HT 2B, 5-HT 2C receptor agonist, entactogen, and weak psychedelic hallucinogen – post-traumatic stress disorder, alcoholism, social anxiety in autism – Multidisciplinary Association for Psychedelic Studies (MAPS), Lykos Therapeutics [1] [2]