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A circular chromosome is a chromosome in bacteria, archaea, mitochondria, and chloroplasts, in the form of a molecule of circular DNA, unlike the linear chromosome of most eukaryotes. Most prokaryote chromosomes contain a circular DNA molecule. This has the major advantage of having no free ends to the DNA.
Circular DNA is DNA that forms a closed loop and has no ends. Examples include: Plasmids, mobile genetic elements; cccDNA, formed by some viruses inside cell nuclei; Circular bacterial chromosomes; Mitochondrial DNA (mtDNA) Chloroplast DNA (cpDNA), and that of other plastids; Extrachromosomal circular DNA (eccDNA)
The bacterial DNA is not packaged using histones to form chromatin as in eukaryotes but instead exists as a highly compact supercoiled structure, the precise nature of which remains unclear. [6] Most bacterial chromosomes are circular, although some examples of linear chromosomes exist (e.g. Borrelia burgdorferi). Usually, a single bacterial ...
The genetic material is freely found in the cytoplasm. Prokaryotes can carry extrachromosomal DNA elements called plasmids, which are usually circular. Linear bacterial plasmids have been identified in several species of spirochete bacteria, including members of the genus Borrelia notably Borrelia burgdorferi, which causes Lyme disease. [3]
In many bacteria, the chromosome is a single covalently closed (circular) double-stranded DNA molecule that encodes the genetic information in a haploid form. The size of the DNA varies from 500,000 to several million base pairs (bp) encoding from 500 to several thousand genes depending on the organism. [2]
A 2006 study purified 4,339 proteins from cultures of strain K-12 and found interacting partners for 2,667 proteins, many of which had unknown functions at the time. [71] A 2009 study found 5,993 interactions between proteins of the same E. coli strain, though these data showed little overlap with those of the 2006 publication. [72] Binary ...
Some bacteria transfer genetic material between cells. This can occur in three main ways. First, bacteria can take up exogenous DNA from their environment in a process called transformation. [136] Many bacteria can naturally take up DNA from the environment, while others must be chemically altered in order to induce them to take up DNA. [137]
More than five decades ago, Jacob, Brenner, and Cuzin proposed the replicon hypothesis to explain the regulation of chromosomal DNA synthesis in E. coli. [18] The model postulates that a diffusible, trans-acting factor, a so-called initiator, interacts with a cis-acting DNA element, the replicator, to promote replication onset at a nearby origin.