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Carcinoid syndrome thus may produce niacin deficiency and clinical manifestations of pellagra. Anti-tuberculosis medication tends to bind to vitamin B 6 and reduce niacin synthesis, since B 6 (pyridoxine) is a required cofactor in the tryptophan-to-niacin reaction. Several therapeutic drugs can provoke pellagra.
A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]
Niacin deficiency is a consequence of a diet low in both niacin and the amino acid tryptophan, a precursor for the vitamin. Low plasma tryptophan is a non-specific indicator, meaning it can have other causes. The signs and symptoms of niacin deficiency start to revert within days of oral supplementation with large amounts of the vitamin. [23] [24]
Bad breath isn't always obvious to the breather, says Hoss. Despite the close proximity of the nose to the mouth, it's hard to tell how our breath smells because we get so used to it from ...
As Lauren Becker, a dentist in New York says, bad breath can be a sign of other oral health issues or illnesses, and that’s apart from the social implications. “If you have good or neutral ...
About 1 in 4 Americans have too much niacin in their body from eating meats and nuts, ... But even though niacin deficiency is a rarity in the U.S., some people do take it as a dietary supplement ...
Pellagra, a condition caused by niacin (vitamin B3) deficiency, may cause a thick greyish fur to develop on the dorsal tongue, along with other oral signs. [9] Transient surface discoloration of the tongue and other soft tissues in the mouth can occur in the absence of hairy tongue.
Niacin has been linked to a higher risk of heart disease. It is often added to flour and fortified cereals in the U.S. The B vitamin used to be a popular medication to lower high cholesterol.