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[143] [144] The miRNA target site of an mRNA transcript can also be blocked by a steric-blocking oligo. [145] For the "in situ" detection of miRNA, LNA [146] or Morpholino [147] probes can be used. The locked conformation of LNA results in enhanced hybridization properties and increases sensitivity and selectivity, making it ideal for detection ...
It is an integrative approach significantly improves on miRNA-target prediction accuracy as assessed by both mRNA and protein level measurements in breast cancer cell lines. Cupid is implemented in 3 steps: Step 1: re-evaluate candidate miRNA binding sites in 3' UTRs.
MicroRNA sequencing (miRNA-seq), a type of RNA-Seq, is the use of next-generation sequencing or massively parallel high-throughput DNA sequencing to sequence microRNAs, also called miRNAs. miRNA-seq differs from other forms of RNA-seq in that input material is often enriched for small RNAs. miRNA-seq allows researchers to examine tissue-specific expression patterns, disease associations, and ...
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It is concluded that the miRNA has an important function in the central pacemaker of the Drosophila circadian rhythm clock. To be more precise Bantam miRNA has an important relation with the clock component clk, thus making it an important factor of study regarding its role in Drosophila behavior.
Many mammalian genomes encode four closely related miR-29 precursors that are transcribed in two transcriptional units. For example, human miR-29a and miR-29b-1 are processed from an intron of a long non-coding transcript pri-miRNA (lnc-pri-miRNA) LOC646329 from chromosome 7. miR-29b-2 (identical in sequence to miR-29b-1) and miR-29c are co-transcribed from chromosome 1.
MicroRNAs function to regulate the expression levels of other genes by several mechanisms, generally reducing protein levels through the cleavage of mRNAs or the repression of their translation. Several targets for miR-132 have been described, including mediators of neurological development , synaptic transmission , inflammation and angiogenesis .
n/a Ensembl ENSG00000207703 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 15: 88.61 – 88.61 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 7-2 is a non-protein-coding gene product that in humans is encoded by the MIR7-2 gene. Function microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional ...