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Bipolar disorder is among the top 20 causes of disability worldwide and leads to substantial costs for society. [21] Due to lifestyle choices and the side effects of medications, the risk of death from natural causes such as coronary heart disease in people with bipolar disorder is twice that of the general population. [4]
Bipolar Disorder and Major Depressive Disorder have been closely linked due to the similar depressive symptoms and similar monoaminergic systems that have been thought to underlie these conditions. Much of the research for bipolar disorder is done in conjunction with studies of other diseases, most commonly schizophrenia and major depressive ...
Bipolar disorder is a long-term mood disorder characterized by major fluctuations in mood — both high and low — that can impact daily functioning and behavior. ... like dopamine and serotonin ...
Bipolar disorder is associated with elevated basal and dexamethasone elicited cortisol and adrenocorticotropic hormone (ACTH). These abnormalities are particularly prominent in mania, and are inversely associated with antipsychotic use. [97] The incidence of psychiatric symptoms associated with corticosteroids is between 6% and 32%.
(2014.) “The prevalence and illness characteristics of DSM-5-defined ‘mixed feature specifier’ in adults with major depressive disorder and bipolar disorder: Results from the International ...
In adults and children with bipolar disorder, SSRIs may cause a bipolar switch from depression into hypomania/mania, mixed states or rapid cycling. [153] When taken with mood stabilizers, the risk of switching is not increased, however when taking SSRIs as a monotherapy, the risk of switching may be twice or three times that of the average.
Biological psychiatry or biopsychiatry is an approach to psychiatry that aims to understand mental disorder in terms of the biological function of the nervous system.It is interdisciplinary in its approach and draws on sciences such as neuroscience, psychopharmacology, biochemistry, genetics, epigenetics and physiology to investigate the biological bases of behavior and psychopathology.
Co-occurring substance misuse disorders, which are extremely common in bipolar patients, can cause a significant worsening of bipolar symptomatology and can cause the emergence of affective symptoms. The treatment options and recommendations for substance use disorders is wide but may include certain pharmacological and nonpharmacological ...
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