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G-quadruplex structures can be computationally predicted from DNA or RNA sequence motifs, [11] [12] but their actual structures can be quite varied within and between the motifs, which can number over 100,000 per genome. Their activities in basic genetic processes are an active area of research in telomere, gene regulation, and functional ...
Hoogsteen pointed out that if the alternative hydrogen-bonding patterns were present in DNA, then the double helix would have to assume a quite different shape. Hoogsteen base pairs are observed in alternative structures such as the four-stranded G-quadruplex structures that form in DNA and RNA.
In molecular biology, a guanine tetrad (also known as a G-tetrad or G-quartet) is a structure composed of four guanine bases in a square planar array. [ 1 ] [ 2 ] They most prominently contribute to the structure of G-quadruplexes , where their hydrogen bonding stabilizes the structure.
RNA i-motif structure showing cytosine bases in the quadruplex. 7] C·C + base pairing found in i-motif structures. [8] Base-pairing energy=169.7 kJ/mol. [9] Similar to G-quadruplex DNA structures with intercalated guanine residues, i-motifs consists of antiparallel tracts of oligodeoxynucleotides strands that contain mostly cytosine residues.
G-quadruplexes, also known as G4 DNA are secondary structures found in nucleic acids that are rich in guanine. [1] These structures are normally located at the telomeres (the ends of the chromosomes). The G-quadruplex can either be parallel or antiparallel depending on the loop configuration, which is a component of the structure.
Pages in category "G-quadruplex" The following 4 pages are in this category, out of 4 total. This list may not reflect recent changes. ...
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One of the weaker sections within the G-quadruplex wikipedia was on the Quadruplex prediction techniques, a review which may assist in offering more information on the techniques used is "Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes" by Julian Leon Huppert.