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DHX36 exhibits a unique ATP-dependent guanine-quadruplex (G4) resolvase activity and specificity for its substrate in vitro. [10] [11] DHX36 displays repetitive unwinding activity as a function of the thermal stability of the G-quadruplex substrate, characteristic of a number of other G-quadruplex resolvases such as the BLM/WRN helicases.
Such a quadruplex is described as tetramolecular, reflecting the requirement of four separate strands. The term G4 DNA was originally reserved for these tetramolecular structures that might play a role in meiosis. [5] However, as currently used in molecular biology, the term G4 can mean G-quadruplexes of any molecularity.
This work lead to a high-resolution structure of a DNA quadruplex [3] and structural studies on protein-drug complexes, such as that of diaphorase with CB1954 (ChesterBeatty 1954), an anticancer prodrug. Neidle was appointed to the Chair of Biophysics at ICR in 1990, and then made Academic Dean 1997–2002. [4]
In molecular biology, a guanine tetrad (also known as a G-tetrad or G-quartet) is a structure composed of four guanine bases in a square planar array. [1] [2] They most prominently contribute to the structure of G-quadruplexes, where their hydrogen bonding stabilizes the structure.
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These cores characterize phenanthroline derivatives due to their G4 binding and telomerase inhibiting activity. [43] This activity leads to an overall increase in the T m of the i-motif. Phenanthroline derivatives bind to the C:C base pair, leading to a decrease in the binding constant lower than that of a normal G-quadruplex. [44]
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