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Arginine alpha-ketoglutarate (AAKG) is a salt of the amino acid arginine and alpha-ketoglutaric acid. It is marketed as a bodybuilding supplement. [1] Peer-reviewed studies have found no increase in muscle protein synthesis or improvement in muscle strength from use of AAKG as a dietary supplement. [1] [2] [3]
Delocalization of charge in guanidinium group of l-Arginine. The amino acid side-chain of arginine consists of a 3-carbon aliphatic straight chain, the distal end of which is capped by a guanidinium group, which has a pK a of 13.8, [39] and is therefore always protonated and
It contains L-arginine hydrochloride and L-lysine hydrochloride. [2] The most common side effects include nausea and vomiting. [2] Arginine/lysine is also associated with hyperkalaemia (high blood potassium levels), but the frequency of this side effect is not known. [2] Side effects with arginine/lysine are usually mild or moderate. [2]
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Various adverse effects may occur according to the pre-workout product and dose of supplement consumed. [10] Some potential side effects of taking pre-workout could include nausea and skin irritation. [81] Other adverse effects have been shown to arise when the product contains ingredients such as synephrine and caffeine.
α-Ketoglutarate is a component of the citric acid cycle, a cyclical metabolic pathway located in the mitochondria.This cycle supplies the energy that cells need by sequentially metabolizing (indicated by →) citrate through seven intermediate metabolites and then converting the eighth intermediate metabolite, oxaloacetate, back to citrate: [2]
Creatine-alpha-ketoglutarate is a salt formed from alpha-ketoglutaric acid (AKG) and creatine. Creatine is a mass-produced fitness supplement that is supposed to increase the user's muscle mass, strength and power. Creatine requires a delivery system for cell uptake. [citation needed] An example is arginine alpha-ketoglutarate.
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