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The immune system extends this response to its treatments of self-antigens, softening reactions against allergens, the body, [9] and digestive microorganisms. [15] As the worms developed ways of triggering a beneficial immune response, humans came to rely on parasitic interaction to help regulate their immune systems.
Resistance to antiparasitics has been a growing concern, especially in veterinary medicine. The Egg hatch assay can be used to determine whether a parasite causing an infection has become resistant to standard drug treatments. [10]
Drugs are frequently used to kill parasites in the host. In earlier times, turpentine was often used for this, but modern drugs do not poison intestinal worms directly. Rather, anthelmintic drugs now inhibit an enzyme that is necessary for the worm to make the substance that prevents the worm from being digested. [citation needed]
Rapid treatment may kill adult worms and thereby stop further worsening of symptoms. [4] Both medications are considered safe but have been associated with side effects such as bone marrow suppression. [4] Their use during pregnancy or in children under the age of 2 years is poorly studied but appears to be safe. [4]
Outside of these initial symptoms that can arise, there are other worries attached to using live helminth parasites as treatment including: Ethical perspective: using living things as treatment [43] Symptoms re-occurring post treatment [43] Worm adaption if in a colitis host [43]
Ivermectin is an antiparasitic drug. [7] After its discovery in 1975, [8] its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. [9] Approved for human use in 1987, [10] it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis.
The most common treatments for hookworm are benzimidazoles, specifically albendazole and mebendazole. BZAs kill adult worms by binding to the nematode's β-tubulin and subsequently inhibiting microtubule polymerization within the parasite. [14] In certain circumstances, levamisole and pyrantel pamoate may be used. [12]
Infected organisms that show symptoms will range in severity depending on the number of parasites. [1] When the number of trematodes is high, signs of infection include severe pain in the abdomen. [1] The signs and symptoms of the disease is also impacted by the location and spread of the parasite in the body. [9]
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