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Pholcodine is found in certain cough lozenges, [2] and more commonly as an oral solution, typically 5 mg / 5 ml. Adult dosage is 5-10 ml up to 3-4 times daily. [3] Pholcodine now largely replaces the previously more common codeine linctus, as it has a much lower potential for dependence.
Dosage typically includes information on the number of doses, intervals between administrations, and the overall treatment period. [3] For example, a dosage might be described as "200 mg twice daily for two weeks," where 200 mg represents the individual dose, twice daily indicates the frequency, and two weeks specifies the duration of treatment.
While it predates the term, it is often classified as a nonsteroidal anti-inflammatory drug (NSAID). Phenazone was one of the earliest synthetic medications — when it was patented in 1883, the only synthetic medical chemicals on the market were chloral hydrate , a sedative (as well as at least one derivative of that chemical), trimethylamine ...
The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.
Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]
The very ambiguous terms "percent solution" and "percentage solutions" with no other qualifiers, continue to occasionally be encountered. This common usage of % to mean m/v in biology is because of many biological solutions being dilute and water-based, an aqueous solution. Liquid water has a density of approximately 1 g/cm 3 (1 g/mL). Thus 100 ...
Percentage solution may refer to: Mass fraction (or "% w/w" or "wt.%"), for percent mass; Volume fraction (or "% v/v" or "vol.%"), volume concentration, for percent volume "Mass/volume percentage" (or "% m/v") in biology, for mass per unit volume; incorrectly used to denote mass concentration (chemistry). See usage in biology
The fixed-dose procedure (FDP), proposed in 1992 by the British Toxicology Society, is a method to assess a substance's acute oral toxicity. [ 1 ] [ 2 ] In comparison to the older LD 50 test developed in 1927, this procedure produces similar results while using fewer animals and causing less pain and suffering. [ 3 ]