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Hypoxic ventilatory response (HVR) is the increase in ventilation induced by hypoxia that allows the body to take in and transport lower concentrations of oxygen at higher rates. It is initially elevated in lowlanders who travel to high altitude, but reduces significantly over time as people acclimatize .
Ventilation is normally unconscious and automatic, but can be overridden by conscious alternative patterns. [3] Thus the emotions can cause yawning, laughing, sighing (etc.), social communication causes speech, song and whistling, while entirely voluntary overrides are used to blow out candles, and breath holding (for instance, to swim underwater).
Hypoxic pulmonary vasoconstriction (HPV), also known as the Euler-Liljestrand mechanism, is a physiological phenomenon in which small pulmonary arteries constrict in ...
Hypoxic ventilatory response (HVR) is the increase in ventilation induced by hypoxia that allows the body to take in and transport lower concentrations of oxygen at higher rates. It is initially elevated in lowlanders who travel to high altitude, but reduces significantly over time as people acclimatize .
Depletion of mAKAP or disruption of its targeting to the perinuclear (in cardiomyocytes) region altered the stability of HIF-1 and transcriptional activation of genes associated with hypoxia. Thus, "compartmentalization" of oxygen-sensitive signaling components may influence the hypoxic response. [28]
The physiological responses to high altitude include hyperventilation, polycythemia, increased capillary density in muscle and hypoxic pulmonary vasoconstriction–increased intracellular oxidative enzymes. There are a range of responses to hypoxia at the cellular level, shown by discovery of hypoxia-inducible factors (HIFs), which determine ...
A decreased respiratory drive can also be the result of metabolic alkalosis, a state of decreased carbon dioxide in the blood; Central sleep apnea. During sleep, the breathing centers of the brain can pause their activity, leading to prolonged periods of apnea with potentially serious consequences. Hyperventilation followed by prolonged breath ...
These methods can be used to mimic some forms of hypoxic hypoxia and they are currently being studied including the detection of variation in arterial CO 2 tension acting as a quick-response-system for short term (or emergency) regulation.