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A total review of metformin use during pregnancy compared to insulin alone found good short-term safety for both the mother and baby, but safety in the longer term is unclear. [61] Several observational studies and randomized controlled trials found metformin to be as effective and safe as insulin for the management of gestational diabetes.
One theory is that metformin has anti-tumor side effects because it lowers insulin levels and keeps tumor cells from multiplying. ... the clinical pregnancy rate for those using metformin versus a ...
Prepare for potential side effects. Taking metformin may cause unpleasant side effects like diarrhea, nausea, and an upset stomach. Taking it with food can reduce the risk.
Generally speaking, GLP-1s, GIP/GLP-1s, and metformin are considered safe and effective when used as prescribed. That said, no medication is without side effects.
Some dietary supplements can cause side effects and harm to the mother or unborn child. [5] Pregnant women should discuss all dietary supplements with their health care professional to determine the appropriate dosage and which supplements are safe during pregnancy. [5]
They work best with patients over 40 years old who have had diabetes mellitus for under ten years. They cannot be used with type 1 diabetes, or diabetes of pregnancy. They can be safely used with metformin or glitazones. The primary side-effect is hypoglycemia, which appears to happen more commonly with sulfonylureas than with other treatments ...
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Treatment of polycystic ovarian syndrome with metformin during pregnancy has been noted to decrease GDM levels. [94] Almost half of the women did not reach sufficient control with metformin alone and needed supplemental therapy with insulin; compared to those treated with insulin alone, they required less insulin, and they gained less weight. [95]
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