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It is unclear if use during pregnancy is safe for the fetus. [6] Timolol is a non-selective beta blocker. [3] Timolol was patented in 1968, and came into medical use in 1978. [7] It is on the World Health Organization's List of Essential Medicines. [8] Timolol is available as a generic medication.
Pregnancy category: AU: C [1] Routes of administration: Eye drops: ATC code: S01ED51 ; ... Travoprost/timolol, sold under the brand name Duotrav among others, ...
Brimonidine is an α 2 adrenergic agonist. [4]Peripheral α 2 agonist activity results in vasoconstriction of blood vessels (as opposed to central α 2 agonist activity that decreases sympathetic tone, as can be seen by the medication clonidine).
Use during pregnancy or breastfeeding is generally not recommended. [5] It is a prostaglandin analog and works by increasing the outflow of aqueous fluid from the eyes. [4] Travoprost was approved for medical use in the United States and in the European Union in 2001. [4] [3] It is available as a generic medication in the United Kingdom. [5]
It is also available as the combination dorzolamide/timolol. [3] [4] Common side effects include eye discomfort, eye redness, taste changes, and blurry vision. [3] Serious side effects include Steven Johnson syndrome. [3] Those allergic to sulfonamides may be allergic to dorzolamide. [3] [5] Use is not recommended in pregnancy or breastfeeding. [5]
Brimonidine/timolol, sold under the brand name Combigan among others, is a fixed-dose combination medication eye drop used for the treatment of glaucoma. [1] It is a combination of brimonidine (an α 2 adrenergic agonist) and timolol (a β adrenergic blocker).
Several reports have demonstrated the efficacy of topical application of the beta-adrenergic antagonist timolol in the treatment of pediatric pyogenic granuloma. [14] Usually, no treatment is used if the pyogenic granuloma occurs during pregnancy, since the lesion may heal spontaneously.
Tocolytics are used in preterm labor, which refers to when a baby is born too early before 37 weeks of pregnancy. As preterm birth represents one of the leading causes of neonatal morbidity and mortality, the goal is to prevent neonatal morbidity and mortality through delaying delivery and increasing gestational age by gaining more time for other management strategies like corticosteroids ...