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Remyelination is the process of propagating oligodendrocyte precursor cells to form oligodendrocytes to create new myelin sheaths on demyelinated axons in the Central nervous system (CNS). This is a process naturally regulated in the body and tends to be very efficient in a healthy CNS. [ 1 ]
“By carefully studying the biology of remyelination, we’ve developed a precise therapy to activate it — the first of a new class of MS therapies,” he added. Animal and phase 1 human trials ...
Human axon growth rates can reach 2 mm/day in small nerves and 5 mm/day in large nerves. [4] The distal segment, however, experiences Wallerian degeneration within hours of the injury; the axons and myelin degenerate, but the endoneurium remains. In the later stages of regeneration the remaining endoneurial tube directs axon growth back to the ...
Oligodendrocytes are a type of glial cell, non-neuronal cells in the central nervous system.They arise during development from oligodendrocyte precursor cells (OPCs), [8] which can be identified by their expression of a number of antigens, including the ganglioside GD3, [9] [10] [11] the NG2 chondroitin sulfate proteoglycan, and the platelet-derived growth factor-alpha receptor subunit (PDGF ...
Myelin (/ ˈ m aɪ. ə l ɪ n / MY-ə-lin) is a lipid-rich material that surrounds nerve cell axons to insulate them and increase the rate at which electrical impulses (called action potentials) pass along the axon. [1] [2] The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around it. However ...
A myelinoid or myelin organoid is a three dimensional in vitro cultured model derived from human pluripotent stem cells (hPSCs) that represents various brain regions, the spinal cord or the peripheral nervous system in early fetal human development.
Ocean Drive continues to follow CR 619 north through Ocean City before meeting CR 623. It follows CR 623 for several blocks to the northwest on 34th Street before following CR 656 (Bay Avenue) through Downtown Ocean City, where it crosses the intersection with 9th Street, which provides access to Route 152.
Ocean City is a city in Cape May County, in the U.S. state of New Jersey.It is the principal city of the Ocean City metropolitan statistical area, which encompasses all of Cape May County, and is part of the Philadelphia-Wilmington-Camden, PA-NJ-DE-MD combined statistical area, also known as the Delaware Valley or Philadelphia metropolitan area. [21]