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The same gene variant, or group of gene variants, may produce different effects in different populations depending on differences in the gene variants, or groups of gene variants, they interact with. One example is the rate of progression to AIDS and death in HIV –infected patients.
The concept of "race" as a classification system of humans based on visible physical characteristics emerged over the last five centuries, influenced by European colonialism. [ 12 ] [ 18 ] However, there is widespread evidence of what would be described in modern terms as racial consciousness throughout the entirety of recorded history .
White Americans have far higher incident rates of melanoma of the skin or skin cancer than any other race/ethnicity in the US. In 2007 incident rates among white American males were approximately 25/100,000 people, whereas the next highest group (Hispanics and natives) has an incidence rate of approximately 5/100,000 people. [44]
A wide range of methods have been developed to assess the structure of human populations with the use of genetic data. Early studies of within and between-group genetic variation used physical phenotypes and blood groups, with modern genetic studies using genetic markers such as Alu sequences, short tandem repeat polymorphisms, and single nucleotide polymorphisms (SNPs), among others. [11]
Ruvkun discovered the mechanism by which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, let-7, and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a ...
Up-regulation is a process which occurs within a cell triggered by a signal (originating internal or external to the cell), which results in increased expression of one or more genes and as a result the proteins encoded by those genes. Conversely, down-regulation is a process resulting in decreased gene and corresponding protein expression.
Regulation of biological processes occurs when any process is modulated in its frequency, rate or extent. Biological processes are regulated by many means; examples include the control of gene expression , protein modification or interaction with a protein or substrate molecule .
The use of the term Genetic epidemiology emerged in the mid-1980s as a new scientific field.. In formal language, genetic epidemiology was defined by Newton Morton, one of the pioneers of the field, as "a science which deals with the etiology, distribution, and control of disease in groups of relatives and with inherited causes of disease in populations". [2]