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A new study published today in Nature Biotechnology warns that CRISPR may not be the ultra-specific gene editor we've believed it to be. With CRISPR-Cas9, researchers can find particular sequences ...
CRISPR technology has been shown to work efficiently in the treatment of heart disease. ... unintended consequences in the target species as well as non-target ...
This technology has transformed fields such as genetics, medicine, [179] [180] and agriculture, [181] [182] offering potential treatments for genetic disorders, advancements in crop engineering, and research into the fundamental workings of life. However, its ethical implications and potential unintended consequences have sparked significant ...
Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies such as: clustered, regularly interspaced, short palindromic repeats ()-Cas9, transcription activator-like effector nucleases (), meganucleases, and zinc finger nucleases (ZFN). [1]
It’s unclear what effects an off-target edit would have on a patient, but the fear is that it could result in unintended health consequences down the road, Thompson said. “To date, there do ...
CRISPR gene editing technology in humans has the potential to cause profound social impacts, [112] such as in the long-term prevention of diseases in humans. [113] However, He's human experiments raised ethical concerns the effect are unknown on future generations. [ 112 ]
CRISPR technology is a promising tool not only for genetic disease corrections but also for the prevention of viral and bacterial infections. Utilizing CRISPR–Cas therapies, researchers have targeted viral infections like HSV-1, EBV, HIV-1, HBV, HPV, and HCV, with ongoing clinical trials for an HIV-clearing strategy named EBT-101 ...
A gene drive is a natural process [1] and technology of genetic engineering that propagates a particular suite of genes throughout a population [2] by altering the probability that a specific allele will be transmitted to offspring (instead of the Mendelian 50% probability). Gene drives can arise through a variety of mechanisms.