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In organic chemistry, the Mannich reaction is a three-component organic reaction that involves the amino alkylation of an acidic proton next to a carbonyl (C=O) functional group by formaldehyde (H−CHO) and a primary or secondary amine (−NH2) or ammonia (NH3). [ 1 ] The final product is a β-amino-carbonyl compound also known as a Mannich base.
Carl Ulrich Franz Mannich (8 March 1877 in Breslau – 5 March 1947 in Karlsruhe) was a German chemist. From 1927 to 1943 he was professor for pharmaceutical chemistry at the University of Berlin. His areas of expertise were keto bases, alcohol bases, derivatives of piperidine, papaverine, lactones and also Digitalis - glycosides.
A Mannich base is a beta-amino-ketone, which is formed in the reaction of an amine, formaldehyde (or an aldehyde) and a carbon acid. [1] The Mannich base is an endproduct in the Mannich reaction, which is nucleophilic addition reaction of a non-enolizable aldehyde and any primary or secondary amine to produce resonance stabilized imine (iminium ion or imine salt).
The nitro-Mannich reaction (or aza-Henry reaction) is the nucleophilic addition of a nitroalkane (or the corresponding nitronate anion) to an imine, resulting in the formation of a beta-nitroamine. [1] With the reaction involving the addition of an acidic carbon nucleophile to a carbon-heteroatom double bond, the nitro-Mannich reaction is ...
The aza-Cope/Mannich reaction is a synthetically powerful reaction, as it is able to create complex cyclic molecules from simple starting materials. This tandem reaction provides a thermodynamic bias towards one rearrangement product, as the Mannich cyclization is irreversible and its product, an acyl substituted pyrrolidine ring, more stable ...
Borylation occurs selectively at the least sterically hindered and least electron rich primary C–H bond in a range of acetals, ethers, amines, and alkyl fluorides. [10] Additionally, no reaction is shown to occur in the absence of primary C–H bonds, for example when cyclohexane is the substrate.
In chemistry, a reaction mechanism is the step by step sequence of elementary reactions by which overall chemical reaction occurs. [1] A chemical mechanism is a theoretical conjecture that tries to describe in detail what takes place at each stage of an overall chemical reaction. The detailed steps of a reaction are not observable in most cases ...
The stereoselectivity of this reaction was further investigated through study of prochiral methylene hydrogen discrimination. [6] This is due to the extra chiral center at C-2. [7] This process occurs through an oxidation, which regenerates the pyrrolinium cation and formation of an enolate anion, and an intramolecular Mannich reaction.