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The first Iteration was prior to 1998. In 1999, the FDA released version 2.0. CTCAE version 4.0 in 2009 with an update to y version 4.03 in 2010. [2] The current version 5.0 was released on November 27, 2017. Many clinical trials, now extending beyond oncology, encode their observations based on the CTCAE system. It uses a range of grades from ...
This work assessed the geologic history of the currently defined eons and eras of the pre-Cambrian, [note 2] and the proposals in the "Geological Time Scale" books 2004, [74] 2012, [5] and 2020. [75] Their recommend revisions [ 4 ] of the pre-Cryogenian geologic time scale were (changes from the current scale [v2023/09] are italicised):