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The strength of topical hydrocortisone products ranges from 0.1% to 2.5%, which means there could be 1 mg to 25 mg hydrocortisone in 1g of the products. [12] Some formulations for topical hydrocortisone include hydrocortisone 0.5% cream or ointment, hydrocortisone 1% cream or ointment, and hydrocortisone 2.5% cream or ointment. [34]
Gels have a jelly-like property and dry in a thin and watery film. Gel formulations have therapeutic effects as good as ointments and appearance as cosmetically appealing as creams, resulting in a high patient acceptance. [4] Gels are absorbed readily and are appropriate for distributing topical glucocorticoids to hairy areas.
Side effects may occur from sudden discontinuation and prolonged, continuous use can lead to skin thinning. [2] Intermittent use of topical steroids for atopic dermatitis is safe and does not cause skin thinning. [3] [4] [5]
In people with psoriasis using topical steroids it occurs in up to 5% of people after a year of use. [5] Intermittent use of topical steroids for atopic dermatitis is safe and does not cause skin thinning. [6] [7] [8] Skin atrophy can occur with both prescription and over the counter steroids creams. [9]
Hydrocortisone is the pharmaceutical term for cortisol used in oral administration, intravenous injection, or topical application.It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients needing steroid treatment but unable to take oral medication, and perioperatively in ...
In severe cases, oral or injectable corticosteroids may be used. While these usually bring about rapid improvements, they have greater side effects. Long term use of topical steroids may result in skin atrophy, stria, and telangiectasia. [5] Their use on delicate skin (face or groin) is therefore typically with caution. [5]
Common side effects include skin irritation, dry skin, redness, pimples, and telangiectasia. [8] Serious side effects may include adrenal suppression, allergic reactions, cellulitis, and Cushing's syndrome. [8] Use in pregnancy and breastfeeding is of unclear safety. [12] Clobetasol is believed to work by activating steroid receptors. [8]
The safety of desonide has not been determined beyond 4 weeks of use. [2] Patients with allergies to corticosteroids (like hydrocortisone or prednisone) should use caution when taking desonide. [3] Pharmacists and prescribing physicians should be aware that this medication may contain inactive ingredients than can cause allergic reactions.
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