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Aziridine is an organic compound consisting of the three-membered heterocycle C 2 H 5 N. [5] [6] It is a colorless, toxic, volatile liquid that is of significant practical interest. [7] Aziridine was discovered in 1888 by the chemist Siegmund Gabriel. [8] Its derivatives, also referred to as aziridines, are of broader interest in medicinal ...
Mitomycin C, an aziridine, is used as a chemotherapeutic agent by virtue of its antitumour activity. [1]In organic chemistry, aziridines are organic compounds containing the aziridine functional group (chemical structure (R−) 4 C 2 N−R), a three-membered heterocycle with one amine (>NR) and two methylene bridges (>CR 2).
Aziridiniums are the ionic form of the class of molecules known as aziridines. [1] Aziridines can be used to insert nitrogen atoms during synthesis, but without any substituents attached to the nitrogen in the ring, they are considered nonactivated and inert. [2] They can be rendered active by the preparation of aziridinium ions.
Chemical structure of mitomycin C. The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. [1] [2] They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international nonproprietary name ...
Polyethylenimine (PEI) or polyaziridine is a polymer with repeating units composed of the amine group and two carbon aliphatic CH 2 CH 2 spacers. Linear polyethyleneimines contain all secondary amines, in contrast to branched PEIs which contain primary, secondary and tertiary amino groups.
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Azirines are three-membered heterocyclic unsaturated (i.e. they contain a double bond) compounds containing a nitrogen atom and related to the saturated analogue aziridine. [1] They are highly reactive yet have been reported in a few natural products such as Dysidazirine .
Ring opening of aziridine to form azomethine ylide. In this ring opening reaction, there is an issue of torquoselectivity . Electronegative substituents prefer to rotate outwards, to the same side as the R substituent on the nitrogen, whereas electropositive substituents prefer to rotate inwards.