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In epidemiology, a non-pharmaceutical intervention (NPI) is any method used to reduce the spread of an epidemic disease without requiring pharmaceutical drug treatments. Examples of non-pharmaceutical interventions that reduce the spread of infectious diseases include wearing a face mask and staying away from sick people .
In particular cases, simpler tests like paired difference test, McNemar test and Cochran–Mantel–Haenszel test are available. When the outcome of interest is continuous, estimation of the average treatment effect is performed. Matching can also be used to "pre-process" a sample before analysis via another technique, such as regression ...
Cohort studies represent one of the fundamental designs of epidemiology which are used in research in the fields of medicine, pharmacy, nursing, psychology, social science, and in any field reliant on 'difficult to reach' answers that are based on evidence . In medicine for instance, while clinical trials are used primarily for assessing the ...
Various studies, managed by the Data Center Studies on Congenital Heart Diseases Copenhagen General Population Study (CGPS) Cohort Denmark 1976 170,000 The study is an ongoing prospective cohort study, that investigates the epidemiology of a wide range of diseases in a representative sample of the Danish population. Now integrated with and ...
Clinical epidemiology is a subfield of epidemiology specifically focused on issues relevant to clinical medicine. The term was first introduced by virologist John R. Paul in his presidential address to the American Society for Clinical Investigation in 1938. [1] [2] It is sometimes referred to as "the basic science of clinical medicine". [3]
Epidemiological (and other observational) studies typically highlight associations between exposures and outcomes, rather than causation. While some consider this a limitation of observational research, epidemiological models of causation (e.g. Bradford Hill criteria) [7] contend that an entire body of evidence is needed before determining if an association is truly causal. [8]
A true experiment would, for example, randomly assign children to a scholarship, in order to control for all other variables. Quasi-experiments are commonly used in social sciences, public health, education, and policy analysis, especially when it is not practical or reasonable to randomize study participants to the treatment condition.
Randomized controlled trial [5]. Blind trial [6]; Non-blind trial [7]; Adaptive clinical trial [8]. Platform Trials; Nonrandomized trial (quasi-experiment) [9]. Interrupted time series design [10] (measures on a sample or a series of samples from the same population are obtained several times before and after a manipulated event or a naturally occurring event) - considered a type of quasi ...