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The most common organism used for production of riboflavin through fermentation is Eremothecium ashbyii. Once riboflavin is produced it must be extracted from the broth, this is done by heating the cells for a certain amount of time, and then the cells can be filtered out of solution. Riboflavin is later purified and released as final product. [3]
Riboflavin, also known as vitamin B 2, is a vitamin found in food and sold as a dietary supplement. [3] It is essential to the formation of two major coenzymes, flavin mononucleotide and flavin adenine dinucleotide. These coenzymes are involved in energy metabolism, cellular respiration, and antibody production, as well as normal growth and ...
In 2008, the global need for riboflavin was 6,000 tons per year, with production capacity of 10,000 tons. [4] This $150 to 500 million market is not only for medical applications, but is also used as a supplement to animal food in the agricultural industry and as a food colorant. [4]
Riboflavin synthase is an enzyme that catalyzes the final reaction of riboflavin biosynthesis. It catalyzes the transfer of a four-carbon unit from one molecule of 6,7-dimethyl-8-ribityllumazine onto another, resulting in the synthesis of riboflavin and 5-amino-6-ribitylamino-2,4(1 H ,3 H )-pyrimidinedione :
Flavin mononucleotide is also used as an orange-red food colour additive, designated in Europe as E number E101a. [5] E106, a very closely related food dye, is riboflavin-5′-phosphate sodium salt, which consists mainly of the monosodium salt of the 5′-monophosphate ester of riboflavin. It is rapidly turned to free riboflavin after ingestion.
Flavoproteins are proteins that contain a nucleic acid derivative of riboflavin. These proteins are involved in a wide array of biological processes, including removal of radicals contributing to oxidative stress, photosynthesis, and DNA repair. The flavoproteins are some of the most-studied families of enzymes.
This was followed in the 1950s by the mass production and marketing of vitamin supplements, including multivitamins, to prevent vitamin deficiencies in the general population. [8] Governments have mandated the addition of some vitamins to staple foods such as flour or milk, referred to as food fortification , to prevent deficiencies. [ 9 ]
Industrial enzymes are enzymes that are commercially used in a variety of industries such as pharmaceuticals, chemical production, biofuels, food and beverage, and consumer products. Due to advancements in recent years, biocatalysis through isolated enzymes is considered more economical than use of whole cells.