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The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]
Both enzymes, C4b2b3b and C3bBbC3b, are unstable and undergo decay dissociation with a half-life at 37 °C of approximately 1.5 - 3 min. [1] The properdin stabilizes the alternative pathway C5 convertase of which half-life is at 37 °C 10 - 34 min. [2] [3] In contrast, the fluid phase C5 convertase CVFBb is stable (half-life at 37 °C = 7 h). [10]
The classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway is initiated by antigen-antibody complexes with the antibody isotypes IgG and IgM. [1] [2]
Complement component 5 is a protein that in humans is encoded by the C5 gene. [5] Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b: C5a plays an important role in chemotaxis. [6] C5b forms the first part of the complement membrane attack complex. Deficiency is thought to cause Leiner's disease.
The C1q domain is a conserved protein domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.C1q comprises 6 A, 6 B and 6 C chains.These share the same topology, each possessing a small, globular N-terminal domain, a collagen-like Gly/Pro-rich central region, and a conserved C-terminal region, the C1q domain. [2]
Pages in category "Complement system" The following 48 pages are in this category, out of 48 total. ... Complement component 4; Complement component 5; Complement ...
The alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against infections. The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the C3b protein directly binds a microbe. It can also be ...
Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. C5b-6-7-8 subsequently binds to C9 [3] [4] [5] and acts as a catalyst in the polymerization of C9.