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Homologous desensitization also occurs with cytokine and other types of receptors, such as those of the epidermal growth factor receptor type, but in these cases desensitization is mediated by other types of receptor kinases. [2] Homologous desensitization serves to limit or restrain a cell's responses to stimuli.
These latter two mechanisms allow for desensitization of one GPCR due to the activities of others, or heterologous desensitization. GRKs may also have GAP domains and so may contribute to inactivation through non-kinase mechanisms as well. A combination of these mechanisms may also occur.
In medicine, desensitization is a method to reduce or eliminate an organism's negative reaction to a substance or stimulus. In pharmacology , drug desensitization refers to two related concepts. First, desensitization may be equivalent to drug tolerance and refers to subjects' reactions (positive or negative) to a drug reducing following its ...
It does not act as a chemotactic agent but rather decrease T cell migration suggesting a mechanism of heterologous receptor desensitization. [ 15 ] The second ligand is a fragment of thrombomodulin exerting anti-inflammatory function in mice.
Sugary drinks can drive the risk of type 2 diabetes and cardiovascular disease through both direct and indirect mechanisms, says Dr. Iluyomade.
While heterologous desensitization occurs rapidly at low agonist concentrations, homologous desensitization shows a dose dependent response and usually begins at significantly higher concentrations. [3] [4] Homologous desensitization serves as a mechanism for tachyphylaxis and helps organisms to maintain homeostasis.
The locking mechanism helps avoid spills when carrying soup to a sick friend or chili to a game day — no need to transfer the molten meal to a separate container for transport. What happens if ...
Their playbook is about stronger government controls. Walls, bans, and ever more draconian enforcement mechanisms don't just restrict immigration; they restrict liberty. The human cost is borne ...