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Buruli ulcer (/ b ə ˈ r uː l i /) [2] is an infectious disease characterized by the development of painless open wounds. The disease is limited to certain areas of the world, with most cases occurring in Sub-Saharan Africa and Australia.
Buruli ulcer is caused by the bacterium Mycobacterium ulcerans. [34] It is related to the bacteria that cause tuberculosis and leprosy. Mycobacterium ulcerans produces a toxin, mycolactone, that destroys tissue. [34] The prevalence of Buruli ulcer is unknown. [18] The risk of mortality is low, although secondary infections can be lethal. [35]
The Global Buruli Ulcer Initiative (GBUI) is a World Health Organization (WHO) initiative to coordinate global efforts to control Buruli ulcer, [1] an infectious disease characterized by the development of painless open wounds. [2]
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The bacteria can infect humans and some other animals, causing persistent open wounds called Buruli ulcer. M. ulcerans is closely related to Mycobacterium marinum , from which it evolved around one million years ago, and more distantly to the mycobacteria which cause tuberculosis and leprosy .
English: A map of Africa with shading representing the number of cases of Buruli ulcer in 2018, according to the World Health Organization's Global Health Observatory data repository. Shading is in four levels: 1-150 cases - Yellow 151-300 cases - Orange 301-450 cases - Light red 451+ - Dark red (applies only to Ghana's 630 cases).
Mycolactone is a polyketide-derived macrolide produced and secreted by a group of very closely related pathogenic mycobacteria species including M. ulcerans, M. liflandii (an unofficial designation), M. pseudoshottsii, and some strains of M. marinum.
A study in Ghana showed that this technique has a diagnostic sensitivity of 40% for nodules, which decreases to 30% for ulcers (21). I interpreted that to mean that if you had 20 samples, 10 each true positive/negative, the microscopists would have called 3 or 4 of the true positives as positives, and that the sentence gave no information on ...