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2-Tolidine (orthotolidine, o-tolidine; not to be confused with o-toluidine) is an organic compound with the chemical formula (C 6 H 4 (CH 3)NH 2) 2. Several isomers are known; the 3-tolidine derivative is also important commercially. It is a colorless compound although commercial samples are often colored. It is slightly soluble in water.
o-Toluidine is absorbed through inhalation and dermal contact as well as from the gastrointestinal tract. [19] [13] [20] [21]The metabolism of o-toluidine involves many competing activating and deactivating pathways, including N-acetylation, N-oxidation, and N-hydroxylation, and ring oxidation.
Common side effects include headache, sore throat, eye discomfort, or changes in perception of taste. [3] [2] More significant side effects may include sleepiness. [2] It is unclear if use during pregnancy or breastfeeding is safe. [4] It is an antihistamine and mast cell stabilizer. [5] [2] Olopatadine was patented in 1986 and came into ...
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This year's NFC championship game is an all-NFC East matchup between two teams that have storied histories in the NFL.. The 183rd overall meeting between the Washington Commanders and Philadelphia ...
Therapy can include the use of zinc supplements to reduce the duration of diarrhea in infants and children under the age of 5. [1] Use of oral rehydration therapy has been estimated to decrease the risk of death from diarrhea by up to 93%. [2] Side effects may include vomiting, high blood sodium, or high blood potassium. [1]
Other side effects of gold-containing drugs include kidney damage, itching rash, and ulcerations of the mouth, tongue, and pharynx. Approximately 35% of patients discontinue the use of gold salts because of these side effects. Kidney function must be monitored continuously while taking gold compounds. [5]
Although available commercially, the salt can be prepared from sodium dithionite and formaldehyde: . Na 2 S 2 O 4 + 2 CH 2 O + H 2 O → HO-CH 2-SO 3 Na + HO-CH 2-SO 2 Na. This reaction proceeds quantitatively, such that dithionite can be determined by its conversion to Rongalite, which is far less O 2-sensitive and thus easier to handle.
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