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Viral metagenomics uses metagenomic technologies to detect viral genomic material from diverse environmental and clinical samples. [ 1 ] [ 2 ] Viruses are the most abundant biological entity and are extremely diverse; however, only a small fraction of viruses have been sequenced and only an even smaller fraction have been isolated and cultured.
Viral transformation is the change in growth, phenotype, or indefinite reproduction of cells caused by the introduction of inheritable material. Through this process, a virus causes harmful transformations of an in vivo cell or cell culture .
Videomics (or vide-omics): A video analysis paradigm inspired by genomics principles, where a continuous image sequence (or video) can be interpreted as the capture of a single image evolving through time through mutations revealing 'a scene'. Multiomics: Integration of different omics in a single study or analysis pipeline. [28]
The nucleotide sequence of an individual genome from a population (no matter which the degree of population complexity might be), can be determined either following a biological or molecular cloning event or by deep sequencing of entire viral genomes, in a manner that mutation linkage (assignment of different mutations to the same genome molecule) can be established.
In bioinformatics, sequence analysis is the process of subjecting a DNA, RNA or peptide sequence to any of a wide range of analytical methods to understand its features, function, structure, or evolution. It can be performed on the entire genome, transcriptome or proteome of an organism, and can also involve only selected segments or regions ...
The Viral Bioinformatics Resource Center (VBRC) is an online resource providing access to a database of curated viral genomes and a variety of tools for bioinformatic genome analysis. [1] This resource was one of eight BRCs ( Bioinformatics Resource Centers ) funded by NIAID with the goal of promoting research against emerging and re-emerging ...
ProViDE [15] is an alignment-based binning approach developed by the Innovation Labs of Tata Consultancy Services (TCS) Ltd. for the estimation of viral diversity in metagenomic samples. ProViDE adopts the reverse orthology based approach similar to SOrt-ITEMS for the taxonomic classification of metagenomic sequences obtained from virome datasets.
Viral evolution is an important aspect of the epidemiology of viral diseases such as influenza (influenza virus), AIDS , and hepatitis (e.g. HCV). The rapidity of viral mutation also causes problems in the development of successful vaccines and antiviral drugs , as resistant mutations often appear within weeks or months after the beginning of a ...