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Libby Zion (November 1965 – March 5, 1984) [6] [7] was a freshman at Bennington College in Bennington, Vermont.She took a prescribed MAOI antidepressant, phenelzine, daily. [8] [9] A hospital autopsy revealed traces of cocaine, but other later tests showed no traces.
Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. [1] The symptoms can range from mild to severe, and are potentially fatal. [ 4 ] [ 5 ] [ 2 ] Symptoms in mild cases include high blood pressure and a fast heart rate ; usually without a fever . [ 2 ]
Serotonin syndrome can result when selective serotonin reuptake inhibitors or monoamine oxidase inhibitors mix with buspirone. [2] Severe symptoms of serotonin syndrome include hyperthermia, delirium, and tachycardia that may lead to shock. Often patients with severe general medical symptoms, such as unstable vital signs, will be transferred to ...
A 2009 Advisory Committee to the U.S. Food and Drug Administration found that online anecdotal reports of discontinuation syndrome related to duloxetine included severe symptoms and exceeded prevalence of both paroxetine and venlafaxine reports by over 250% (although acknowledged this may have been influenced by duloxetine being a much newer ...
An abortive serotonin syndrome state, in which some but not all of the symptoms of the full serotonin syndrome are present, has been reported with venlafaxine at mid-range dosages (150 mg per day). [45] A case of a patient with serotonin syndrome induced by low-dose venlafaxine (37.5 mg per day) has also been reported. [46]
More specifically, vortioxetine is a serotonin reuptake inhibitor, agonist of the serotonin 5-HT 1A receptor, partial agonist of the 5-HT 1B receptor, and antagonist of the serotonin 5-HT 1D, 5-HT 3, and 5-HT 7 receptors, as well as an apparent ligand of the β 1-adrenergic receptor.
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Overdose is usually treated symptomatically, especially in the case of serotonin syndrome, which requires treatment with cyproheptadine and temperature control based on the progression of the serotonin toxicity. [87] Patients are often monitored for vitals and airways cleared to ensure that they are receiving adequate levels of oxygen.