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Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. [ 5 ]
H 1 antagonists, also called H 1 blockers, are a class of medications that block the action of histamine at the H 1 receptor, helping to relieve allergic reactions.Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.
Cyproheptadine blocks 5-HT 2A, H1 and is a mild anticholinergic. Methysergide is a 5-HT 2A antagonist and nonselective 5-HT 1 receptor blocker. It causes retroperitoneal fibrosis and mediastinal fibrosis. [citation needed] Quetiapine blocks 5-HT 2A, 5-HT 1A, dopamine receptors D 1 and D 2, histamine receptor H1, and A1 adrenoreceptors.
After chronic dosing of cyproheptadine (a rather high dose of 8-12mg for 5 days... typical doses are 2-4mg), it reduced growth hormone by over 50%. —Preceding unsigned comment added by 204.111.160.135 20:03, 28 April 2009 (UTC) I have added the reference and data to the adverse effects section of the article.
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AH-1058 is a lipophilic antiarrhythmic calcium channel blocker synthesized by the Pharmaceutical Research Laboratories of Ajinomoto Co., Inc in Kawasaki, Japan. [1] It is derived from cyproheptadine, a compound with known antiserotonic, antihistaminic and calcium channel blocking properties.