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A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. [1] [2] Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted ().
A variety of neurotransmitter prodrugs have been developed and used in medicine. [ 1 ] [ 2 ] They can be useful when the neurotransmitter itself is not suitable for use as a pharmaceutical drug owing to unfavorable pharmacokinetic or physicochemical properties, for instance high susceptibility to metabolism , short elimination half-life , or ...
Sometimes drugs are formulated in an inactive form that is designed to break down inside the body to form the active drug. These are called prodrugs.The reasons for this type of formulation may be because the drug is more stable during manufacture and storage as the prodrug form, or because the prodrug is better absorbed by the body or has superior pharmacokinetics (e.g., lisdexamphetamine).
Benzodiazepine prodrugs (3 P) C. Codrugs (7 P) Corticosteroid esters (80 P) N. Neurotransmitter precursors (1 C, 22 P) S. Sex hormone esters and conjugates (7 C, 37 P)
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS) and are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling.
Continuous technological developments, such as digital health technology and smart sensors, encourage innovation in the ostomy care accessory market. The need for advanced treatments is driven by the global aging population, especially those with gastrointestinal issues, since they improve acceptability and user experience overall.
Insulin glargine, for example, is designed to precipitate after injection so it can be slowly absorbed by the body over a longer period than regular insulin would be. [13] Depot injections of insulins have been studied to better replicate the body's natural basal rate of insulin production, and which can be activated by light to control the ...
For example, some products contained the phrase “rich in protein,” and others listed the amount of protein in the product. Researchers found that 13% of the examined products, or 561 items ...