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  2. Ivabradine - Wikipedia

    en.wikipedia.org/wiki/Ivabradine

    Ivabradine, sold under the brand name Procoralan among others, is a medication, which is a pacemaker current (I f) inhibitor, used for the symptomatic management of ...

  3. Pacemaker current - Wikipedia

    en.wikipedia.org/wiki/Pacemaker_current

    Ivabradine is the most specific and selective I f inhibitor and the only member of this family that is now marketed for pharmacological treatment of chronic stable angina in patients with normal sinus rhythm who have a contraindication or intolerance to beta-blockers. Recent studies have also indicated that funny channel inhibition can be used ...

  4. Inappropriate sinus tachycardia - Wikipedia

    en.wikipedia.org/wiki/Inappropriate_sinus...

    Ivabradine has been shown to reduce HR, improve exercise capacity quantitatively, and reduce subjective symptom burden. The drug appears to have a lower proarrhythmic risk and is well tolerated. Ivabradine shows great promise as the possible therapy of choice for beta-blocker intolerant or suboptimally responsive patients with a chronic ...

  5. HCN channel - Wikipedia

    en.wikipedia.org/wiki/HCN_channel

    HCN4 is the main isoform expressed in the sinoatrial node, but low levels of HCN1 and HCN2 have also been reported.The current through HCN channels, called the pacemaker current (I f), plays a key role in the generation and modulation of cardiac rhythmicity, [13] as they are responsible for the spontaneous depolarization in pacemaker action potentials in the heart.

  6. Cardiovascular agents - Wikipedia

    en.wikipedia.org/wiki/Cardiovascular_agents

    Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]

  7. Heart failure - Wikipedia

    en.wikipedia.org/wiki/Heart_failure

    Ivabradine is recommended for people with symptomatic heart failure with reduced left ventricular ejection fraction who are receiving optimized guideline-directed therapy (as above) including the maximum tolerated dose of beta-blocker, have a normal heart rhythm and continue to have a resting heart rate above 70 beats per minute. [114]

  8. Dying To Be Free - The Huffington Post

    projects.huffingtonpost.com/dying-to-be-free...

    That day, in August 2013, Patrick got in the car and put the duffel bag on a seat. Inside was a talisman he’d been given by the treatment facility: a hardcover fourth edition of the Alcoholics Anonymous bible known as “The Big Book.”

  9. Talk:Ivabradine - Wikipedia

    en.wikipedia.org/wiki/Talk:Ivabradine

    Here are links to possibly useful sources of information about Ivabradine. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC