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2. Viagra may help prevent dementia by boosting brain blood flow

   www.aol.com/viagra-may-help-prevent-dementia...

   On why Viagra might help reduce vascular dementia risk, Kukreja said: “Sildenafil is a potent inhibitor of the enzyme phosphodiesterase 5 (PDE5), which breaks down the powerful vasodilator ...

3. PDE5 inhibitor - Wikipedia

   en.wikipedia.org/wiki/PDE5_inhibitor

   Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

4. Sildenafil - Wikipedia

   en.wikipedia.org/wiki/Sildenafil

   Sildenafil's brand name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dysfunction has led to its recreational use. [33] The reasons behind such use include the belief that the drug increases libido, improves sexual performance, [ 33 ] or permanently increases penis size. [ 34 ]

5. How to Get Better Viagra Results in 2025 - AOL

   www.aol.com/better-viagara-results-2025...

   According to the Food and Drug Administration (FDA), it usually takes 30 to 60 minutes for Viagra or generic sildenafil to start producing a noticeable improvement in your climax quality.

6. Is Sildenafil Safe for This Common Male Problem? - AOL

   www.aol.com/sildenafil-safe-common-male-problem...

   Sildenafil is most commonly prescribed to be taken one time per day in doses between 25 and 100 mg for ED. Your healthcare provider will determine the best dosage for you based on a number of factors.

7. Discovery and development of phosphodiesterase 5 inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   Structure-activity relationship (SAR) is demonstrated in figure 5, figure 6 and figure 7. Figure 5 demonstrates the three main groups of sildenafil, R1, R2 and R3. R1 is the pyrazolopyrimidinone ring, R2 the ethoxyphenyl ring and R3 is the methylpiperazine ring. R1 group is responsible for the binding of the drug to its active binding site of ...