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The first four seem to be involved in the hydroxylation of toluene to benzyl alcohol. CYP2E1 seems to be the primary enzyme in the hydroxylation of toluene, accounting for roughly 44% of toluene metabolism; [1] however, there is a great deal of ethnic variability, in the Finnish population for example the primary enzyme is CYP2B6.
Download as PDF; Printable version; In other projects Wikidata item ... This page provides supplementary chemical data on toluene. MSDS sheets. Structure and properties
Toluene is also found in cigarette smoke and car exhaust. If not in contact with air, toluene can remain unchanged in soil or water for a long time. [39] Toluene is a common solvent, e.g. for paints, paint thinners, silicone sealants, [40] many chemical reactants, rubber, printing ink, adhesives (glues), lacquers, leather tanners, and ...
Toxic encephalopathy is a neurologic disorder caused by exposure to neurotoxic organic solvents such as toluene, following exposure to heavy metals such as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse effects to prescription drugs, or exposure to extreme concentrations of any natural toxin such as cyanotoxins found in shellfish or freshwater ...
Toxic leukoencephalopathy may also result from carbon monoxide poisoning, ingestion of methanol, ingestion of ethylene, [8] toluene toxicity, [3] ethanol poisoning, ingestion of methylenedioxymethamphetamine (MDMA or "ecstasy"), or ingestion of paradichlorobenzene, [18] which is a toxic agent in mothballs.
This data is frequently screened for quality, relevancy and ideally contains data for species in multiple trophic levels and/or taxonomic groups. [1] [6] The lowest LC50 in the compiled database is then divided by the assessment factor to calculate the PNEC for that data. The assessment factor applied to acute toxicity data is typically 1000 ...
Here are links to possibly useful sources of information about Toluene toxicity. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC
It is mainly used to manufacture toluene diisocyanate, which is a key raw material in polyurethane chemistry. [4] It is still the starting material used when non-phosgene methods of production of toluene diisocyanate are used. [5] [6] It is also a degradation product of polyurethane materials produced using toluene diisocyanate.