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The inflammatory mediators of RA including cytokines, growth factors, metalloproteinases destroy articular cartilage, subchondral bone, tendons and ligaments.Destructive synovitis leads to bone erosion and causes the ligaments of the spine to become too laxed (loose), eventually resulting in cervical spinal instability (loose neck bones).
Enthesophathy and arthritis of large joints of the lower extremities is more common than the characteristic early-morning back pain seen in adult AS. [13] Ankylosing tarsitis of the ankle is a common feature, as is the more classical findings of seronegative ANA and RF as well as presence of the HLA-B27 allele. [ 13 ]
The spinal canal may become narrowed due to abscesses, granulation tissue, or direct dural invasion resulting in compression of cord and neurological deficits. [3] Kyphosis is a result of the front of the spine collapsing. Injury to the thoracic spine are more likely to result in kyphosis compared to lumbar spine injuries. [3]
In some, the x-ray findings may correspond to symptoms of back stiffness with flexion/extension or with mild back pain. [2] Back pain or stiffness may be worse in the morning. [4] Rarely, large anterior cervical spine osteophytes may affect the esophagus or the larynx and cause pain, difficulty swallowing [5] [6] or even dyspnea. [7]
They also detected a hemangioma, which is a benign growth filled with blood and blood vessels, in the T10 vertebrae of my thoracic spine. These typically won’t cause pain or grow, so because I ...
Spinal abnormalities such as flattening of the lumbar lordosis, exaggeration of the thoracic kyphosis, and hyperextension of the cervical spine lead to limited spinal motion. Hip and shoulder arthritis can occur in some people with ankylosing spondylitis , usually early in the course of the illness.
The spine has several regions which are cervical, thoracic, lumbar and sacral. People usually differentiate these locations as neck pain, upper back pain, low back pain or buttock pain.
Ankylosing spondylitis is a type of arthritis in which there is long-term inflammation of the joints of the spine. [2] Other forms of arthritis may sometimes also lead to ankylosis, including rheumatoid arthritis and reactive arthritis; Osteoarthritis usually confers osteophyte formation, which may eventually fuse across joints. Osteoarthritis ...
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