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[6] [7] It decreases circulating DHT levels by up to about 70%. [8] Dutasteride (brand name Avodart) inhibits all three 5α-reductase isoenzymes and can decrease DHT levels by 95%. [9] [10] It can also reduce DHT levels in the prostate by 97 to 99% in men with prostate cancer.
5-alpha reductase blockers reduce DHT levels, slowing down, stopping, or reversing the effects of male pattern baldness. They can also encourage hair regrowth and increase hair count.
The volume of distribution of finasteride is 76 L. [5] Its plasma protein binding is 90%. [5] The drug has been found to cross the blood–brain barrier, whereas levels in semen were found to be undetectable. [5] Finasteride is extensively metabolized in the liver, first by hydroxylation via CYP3A4 and then by aldehyde dehydrogenase. [5]
Finasteride is one of two 5-alpha reductase inhibitors, along with dutasteride. 5-alpha reductase is an enzyme that your body eventually converts into a hormone called dihydrotestosterone (DHT).
Researchers believe that men affected by androgenetic alopecia tend to have higher levels of the 5-alpha-reductase enzyme, which converts testosterone into DHT, as well as an increased level of ...
5α-Reductase type 1 inactivated male mice have reduced bone mass and forelimb muscle grip strength, which has been proposed to be due to lack of 5α-reductase type 1 expression in bone and muscle. [29] In 5 alpha reductase type 2 deficient males, the type 1 isoenzyme is thought to be responsible for their virilization at puberty. [6]
As a 5-alpha-reductase inhibitor, finasteride works by inhibiting the effects of the enzyme responsible for converting testosterone into dihydrotestosterone (DHT).
This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase.This enzyme is responsible for the conversion of the androgen hormone testosterone into the more potent dihydrotestosterone (DHT) and is essential for the production of neurosteroids like allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol from ...
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