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  2. HBsAg - Wikipedia

    en.wikipedia.org/wiki/HBsAg

    It was discovered to be part of the virus that caused serum hepatitis by virologist Alfred Prince in 1968. Heptavax, a "first-generation" hepatitis B vaccine in the 1980s, was made from HBsAg extracted from the blood plasma of hepatitis patients. More modern vaccines are made from recombinant HBsAg grown in yeast.

  3. Seroconversion - Wikipedia

    en.wikipedia.org/wiki/Seroconversion

    The typical seroconversion timecourse for hepatitis B. Seroconversion plays a major role in the diagnosis and treatment of hepatitis B infections. [60] As in other viral infections, seropositivity indicates that an individual has a sufficiently high concentration of antibody or antigen in the blood to be detectable by standard techniques.

  4. Hepatitis B virus - Wikipedia

    en.wikipedia.org/wiki/Hepatitis_B_virus

    HBsAg (hepatitis B surface antigen) was the first hepatitis B virus protein to be discovered. [15] It consists of small (S), medium (M) and large (L) protein. [16] HBcAg (hepatitis B core antigen) is the main structural protein of HBV icosahedral nucleocapsid and it has function in replication of the virus. [17]

  5. Hepatitis B - Wikipedia

    en.wikipedia.org/wiki/Hepatitis_B

    If the host is able to clear the infection, eventually the HBsAg will become undetectable and will be followed by IgG antibodies to the hepatitis B surface antigen and core antigen (anti-HBs and anti HBc IgG). [39] The time between the removal of the HBsAg and the appearance of anti-HBs is called the window period. A person negative for HBsAg ...

  6. Hepatitis - Wikipedia

    en.wikipedia.org/wiki/Hepatitis

    Viral hepatitis is primarily diagnosed through blood tests for levels of viral antigens (such as the hepatitis B surface or core antigen), anti-viral antibodies (such as the anti-hepatitis B surface antibody or anti-hepatitis A antibody), or viral DNA/RNA. [17] [32] In early infection (i.e. within 1 week), IgM antibodies are found in the blood ...

  7. Breakthrough infection - Wikipedia

    en.wikipedia.org/wiki/Breakthrough_infection

    Breakthrough cases of Hepatitis B are primarily attributed to mutations in the Hepatitis B virus (HBV) that make HBV surface proteins unrecognizable to antibodies produced from the HBV vaccine. [14] [15] [16] Viruses with such mutations are called "vaccine escape mutants".

  8. HBeAg - Wikipedia

    en.wikipedia.org/wiki/HBeAg

    HBeAg is a hepatitis B viral protein, produced by the HBcAg reading frame. It is an indicator of active viral replication ; this means the person infected with Hepatitis B can likely transmit the virus on to another person (i.e. the person is infectious).

  9. Autoimmune hepatitis - Wikipedia

    en.wikipedia.org/wiki/Autoimmune_hepatitis

    Autoimmune hepatitis, formerly known as lupoid hepatitis, plasma cell hepatitis, or autoimmune chronic active hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells, causing the liver to be inflamed.

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