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  2. Oclacitinib - Wikipedia

    en.wikipedia.org/wiki/Oclacitinib

    Oclacitinib lacks the side effects that most JAK inhibitors have in humans; instead, side effects are infrequent, mild, and mostly self-limiting. [13] [14] [16] The most common side effects are gastrointestinal problems (vomiting, diarrhea, and appetite loss) and lethargy. The GI problems can sometimes be alleviated by giving oclacitinib with food.

  3. Janus kinase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Janus_kinase_inhibitor

    A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, [1] is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes.

  4. Ruxolitinib - Wikipedia

    en.wikipedia.org/wiki/Ruxolitinib

    Ruxolitinib (sold under the brand names Jakafi and Jakavi among others, and as Opzelura in cream form) is a medication used for the treatment of intermediate or high-risk myelofibrosis, [6] a type of myeloproliferative neoplasm that affects the bone marrow; [11] [12] polycythemia vera, when there has been an inadequate response to or intolerance of hydroxyurea; [6] [13] and steroid-refractory ...

  5. Tofacitinib - Wikipedia

    en.wikipedia.org/wiki/Tofacitinib

    [8] [9] [10] It is a janus kinase (JAK) inhibitor, [8] [9] discovered and developed by the National Institutes of Health and Pfizer. Common side effects include diarrhea, headache, and high blood pressure. [10] Serious side effects may include infections, cancer, and pulmonary embolism.

  6. Pfizer (PFE) Dermatitis JAK Inhibitor NDA Review Gets Delayed

    www.aol.com/news/pfizer-pfe-dermatitis-jak...

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  7. Abrocitinib - Wikipedia

    en.wikipedia.org/wiki/Abrocitinib

    The most common side effects include nausea (feeling sick), headache, acne, herpes simplex (viral infection of the mouth or the genitals), increased levels of creatine phosphokinase in the blood (an enzyme released into the blood when muscle is damaged), vomiting, dizziness and pain in the upper belly.

  8. Aclaris Stock Up on JAK Inhibitor's Encouraging Activity - AOL

    www.aol.com/news/aclaris-stock-jak-inhibitor...

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  9. Can JAK Inhibitors Challenge Biologics?

    www.aol.com/news/2013-02-20-can-jak-inhibitors...

    If JAK inhibitors can show similarly impressive results, gain approval, and make a splash, then these blockbuster biologics could have some real competition. While the future is promising that "if ...