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A decongestant, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract.The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed effectiveness).
The original formula for Actifed contained pseudoephedrine hydrochloride 60 mg as the nasal decongestant and triprolidine hydrochloride 2.5 mg as the antihistamine. . However, in response to widespread laws requiring products containing pseudoephedrine to be kept behind the pharmacy counter, Pfizer changed Actifed's U.S. formula in late 2006 to contain phenylephrine HCl 10 mg as the nasal ...
Phenylephrine, sold under the brand names Neosynephrine and Sudafed PE among others, is a medication used as a decongestant for uncomplicated nasal congestion in the form of a nasal spray or oral tablet, [5] to dilate the pupil, to increase blood pressure given intravenously in cases of low blood pressure, and to relieve hemorrhoids as a ...
[24] [2] [25] [1] As such, it is an indirectly acting sympathomimetic. [24] [2] [25] [1] Pseudoephedrine significantly crosses into the brain, but has some peripheral selectivity due to its hydrophilicity. [25] [26] Chemically, pseudoephedrine is a substituted amphetamine and is closely related to ephedrine, phenylpropanolamine, and amphetamine.
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NyQuil D contains pseudoephedrine, a decongestant that in some regions (such as the United States) is now placed behind the counters at pharmacy and other retail stores and must be requested by the customer. It contains the following active ingredients (15 mL is one tablespoon, half the recommended adult dose):
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