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Dispase is a protease which cleaves fibronectin, collagen IV, and to a lesser extent collagen I. It is found in some bacteria and can be isolated from culture filtrates of Bacillus polymyxa . It can be extracted, purified, and used in research.
Dispase is used to prevent undesired aggregation of cells, which is beneficial in promoting their separating from the ECM scaffold. Experimentation has shown dispase to be most effective on the surface of a thin tissue, such as a lung in pulmonary tissue regeneration.
Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue.
P. polymyxa might have possible future applications as a soil inoculant in agriculture and horticulture. [4] [5] Biofilms of P. polymyxa growing on plant roots have been shown to produce exopolysaccharides which protect the plants from pathogens.
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina.The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel.
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Tuberculosis; Other names: Phthisis, phthisis pulmonalis, consumption, great white plague: Chest X-ray of a person with advanced tuberculosis: Infection in both lungs is marked by white arrow-heads, and the formation of a cavity is marked by black arrows.
This is an accepted version of this page This is the latest accepted revision, reviewed on 30 December 2024. Condition negatively affecting an organism For other uses, see Disease (disambiguation). "Maladies" redirects here. For the 2012 film, see Maladies (film). "Malady" redirects here. For the American politician, see Regis Malady. "Ailment" redirects here. Not to be confused with Aliment ...