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Low energy levels and stress: The AMP-dependent protein kinase AMPK phosphorylates and thereby activates TSC1-TSC2 by phosphorylating at least 2 residues of TSC2. [7] Hypoxia: The Hypoxia-inducible factor α HIFα induces REDD1 at low oxygen levels. REDD1 has been shown to activate TSC1-TSC2 by neutralisation of AKT dependent inhibition. [8]
Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. [8]The defective degradation of glycogen by the autophagy-lysosome pathway is, at least in part, independent of impaired regulation of mTORC1 and is restored by the combined use of PKB/Akt and mTORC1 pharmacological inhibitors.
TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. TSC1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including TSC2, therefore preventing their ubiquitination and degradation in the proteasome. [6]
Central Rural Sanitation Programme (CRSP) launched in 1986. In 1999 it became the Total Sanitation Campaign (TSC). [89] Multiple objectives including elimination of open defecation, addressing manual scavenging, and good sanitation and waste related practices. [89] PM Jan Dhan Yojana (PM's People's Wealth Scheme) CS MoF: 2014: Financial inclusion
Notre Dame got its biggest bowl win in 30 years over No. 2 Georgia in the Sugar Bowl on Thursday. The Irish scored 17 points in less than a minute sandwiching halftime to build a 20-3 lead over ...
The Kansas City Chiefs are releasing kicker Matthew Wright as Harrison Butker is set to return this week and is expected to play in the Week 15 matchup against the Cleveland Browns.. A week after ...
“It’s so rich,” Canal says in the video. “Like Tom Cruise.” The pastry is so famous, it was immortalized in HBO comedy series “Hacks.”In the Season 3 premiere, fictional superstar ...
Later, TSC introduced the multitasking, multi-user, Unix-like UniFLEX operating system, which requires DMA disk controllers, 8" disk, and sold in small numbers. Several of the TSC computer languages were ported to UniFLEX. During the early 1980s, FLEX was offered by Compusense Ltd as an operating system for the 6809-based Dragon 64 home computer.
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