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The frozen section procedure as practiced today in medical laboratories is based on the description by Dr Louis B. Wilson in 1905. Wilson developed the technique from earlier reports at the request of Dr William Mayo, surgeon and one of the founders of the Mayo Clinic [3] Earlier reports by Dr Thomas S. Cullen at Johns Hopkins Hospital in Baltimore also involved frozen section, but only after ...
As the CCPDMA surgery is frequently performed using frozen section pathology, immediate reporting of positive surgical margin is made, and the tumor can be completely removed in the same day. Traditional pathology processing is called "bread loafing", and only allows for the partial examination of the surgical margin.
Frozen section procedure: tissue embedded in optimal cutting temperature compound, mounted on a chuck in a cryostat and ready for section production. Optimal cutting temperature compound (OCT compound) is used to embed tissue samples prior to frozen sectioning on a microtome-cryostat. This process is undertaken so as to mount slices (sections ...
Toluidine blue is also commonly used to stain frozen sections (rapid microscopic analysis of a specimen). Because time is of the essence for a frozen section, toluidine blue allows for the frozen section to be stained and reviewed in 10 to 20 seconds. [4] The other staining method for frozen sections (rapid H&E) takes approximately 60 to 90 ...
Modern frozen section method. Frozen section histology does not give the added margin of safety by the cytotoxic Mohs paste, [14] originally used by Mohs. This paste might have destroyed any residual cancer cells not detected by the pathologist. Missing epidermal margins. Ideally, the Mohs section should include 100% of the epidermal margin ...
Frozen shoulder is a condition that causes pain and immobility to the shoulder in middle age. Primary care sports physician Dr. Stuek discusses why it happens and how to manage.
One’s biological age, which measures the body’s physiological state, may help predict who is at risk for developing colon polyps, a known risk factor for colorectal cancer.
Louis Blanchard Wilson (December 22, 1866 – October 5, 1943) [1] was an American pathologist and the chief of pathology at Mayo Clinic from 1905 to 1937. Wilson is most famous for initiating the routine use of the frozen section procedure for rapid intraoperative diagnosis. [2] Wilson received his medical degree from the University of ...