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2. Alcohol withdrawal syndrome - Wikipedia

   en.wikipedia.org/wiki/Alcohol_withdrawal_syndrome

   During acute alcohol withdrawal, changes also occur such as upregulation of alpha4 containing GABA A receptors and downregulation of alpha1 and alpha3 containing GABA A receptors. Neurochemical changes occurring during alcohol withdrawal can be minimized with drugs which are used for acute detoxification.

3. Post-acute-withdrawal syndrome - Wikipedia

   en.wikipedia.org/wiki/Post-acute-withdrawal_syndrome

   A protracted withdrawal syndrome can occur with symptoms persisting for months to years after cessation of substance use. Benzodiazepines, opioids, alcohol, and any other drug may induce prolonged withdrawal and have similar effects, with symptoms sometimes persisting for years after cessation of use. Psychosis including severe anxiety and ...

4. Kindling (sedative–hypnotic withdrawal) - Wikipedia

   en.wikipedia.org/wiki/Kindling_(sedative...

   Failure to manage the alcohol withdrawal syndrome appropriately can lead to permanent brain damage or death. [11] Acamprosate, a drug used to promote abstinence from alcohol, an NMDA antagonist drug, reduces excessive glutamate activity in the central nervous system and thereby may reduce excitotoxicity and withdrawal related brain damage. [12 ...

5. Drug withdrawal - Wikipedia

   en.wikipedia.org/wiki/Drug_withdrawal

   Drug withdrawal, drug withdrawal syndrome, or substance withdrawal syndrome [1] is the group of symptoms that occur upon the abrupt discontinuation or decrease in the intake of pharmaceutical or recreational drugs. In order for the symptoms of withdrawal to occur, one must have first developed a form of drug dependence.

6. Alcohol detoxification - Wikipedia

   en.wikipedia.org/wiki/Alcohol_detoxification

   Alcohol detoxification (also known as detox) is the abrupt cessation of alcohol intake in individuals that have alcohol use disorder. This process is often coupled with substitution of drugs that have effects similar to the effects of alcohol in order to lessen the symptoms of alcohol withdrawal. When withdrawal does occur, it results in ...

7. Substance use disorder - Wikipedia

   en.wikipedia.org/wiki/Substance_use_disorder

   "Substance use pertains to using select substances such as alcohol, tobacco, illicit drugs, etc. that can cause dependence or harmful side effects."On the other hand, substance abuse is the use of drugs such as prescriptions, over-the-counter medications, or alcohol for purposes other than what they are intended for or using them in excessive ...

8. Glossary of alcohol (drug) terms - Wikipedia

   en.wikipedia.org/wiki/Glossary_of_alcohol_(drug...

   Alcohol detoxification (also known as detox) is the abrupt cessation of alcohol intake in individuals that have alcohol use disorder. This process is often coupled with substitution of drugs that have effects similar to the effects of alcohol in order to lessen the symptoms of alcohol withdrawal.

9. Naltrexone - Wikipedia

   en.wikipedia.org/wiki/Naltrexone

   Effects begin within 30 minutes, [8] though a decreased desire for opioids may take a few weeks to occur. [8] Side effects may include trouble sleeping, anxiety, nausea, and headaches. [8] In those still on opioids, opioid withdrawal may occur. [8] Use is not recommended in people with liver failure. [8] It is unclear if use is safe during ...